Cutaneous Immune Defenses Against Staphylococcus aureus Infections
نویسندگان
چکیده
Staphylococcus aureus (S. aureus) is a virulent bacterium that abundantly colonizes inflammatory skin diseases. Since S. aureus infections occur in an impaired skin barrier, it is important to understand the protective mechanism through cutaneous immune responses against S. aureus infections and the interaction with Staphylococcal virulence factors. In this review, we summarize not only the pathogenesis and key elements of S. aureus skin infections, but also the cutaneous immune system against its infections and colonization. The information obtained from this area may provide the groundwork for further immunomodulatory therapies or vaccination strategies to prevent S. aureus infections.
منابع مشابه
Colonization and Infection of the Skin by S. aureus: Immune System Evasion and the Response to Cationic Antimicrobial Peptides
Staphylococcus aureus (S. aureus) is a widespread cutaneous pathogen responsible for the great majority of bacterial skin infections in humans. The incidence of skin infections by S. aureus reflects in part the competition between host cutaneous immune defenses and S. aureus virulence factors. As part of the innate immune system in the skin, cationic antimicrobial peptides (CAMPs) such as the β...
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Epidemiology and Transmission 487 Staphylococcus aureus 487 Coagulase-Negative Staphylococci 488 Microbiology 489 Staphylococcus aureus 489 Coagulase-Negative Staphylococci 490 Pathogenesis of Disease 490 Virulence Factors of Staphylococcus aureus 490 Epithelial Attachment and Invasion 490 Innate Immune Resistance 491 Secreted Toxins 492 Quorum Sensing and Regulation of Virulence Factor Express...
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